Chipping away at the genetics of smoking behavior

ChIPping away at gene regulation.

The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding...

Chipping away at stem cells.

U recently, conventional wisdom has held that the lineage potential of stem cells was restricted to the tissue of origin. That is, stem cells derived from tissue A could only give rise to differentiated cells of tissue A and not to differentiated cells of tissues B, C, or D. This notion has been challenged since by a plethora of reports suggesting that stem cells have an inherent plasticity tha...

Chipping away at the old block

Survivors of acquired brain injury (ABI) are at risk of a range of neuropsychiatric and behavioural disorders. Emotional disturbance, with reactive elements of mood disorder, such as depression and anxiety, appear particularly common. Specific anxiety disorders, such as post-traumatic stress disorder (PTSD) have also been identified. Pain syndromes are also common-particularly in those who have...

Chipping Away at the Perception/Production Interface

Chipping Away at the Economic Loss Rule

I n its decision of Philippe H. Moransais v. Paul S. Heathman, et al., 24 Fla. L. Weekly S308 (Fla. July 1, 1999),1 the Florida Supreme Court held the Economic Loss Rule (ELR) to be inapplicable to negligence actions against engineers and other professionals. This sudden but welcome detour arrived after more than a decade of case law which stretched, sculpted, and misapplied a product liability...